Here is the order that guitar effects should be placed in generally. Signal from the guitar would arrive at the noise gate first, then go through the effects chain, exiting from the longer delay effects and then go into the speakers.

Noise reduction

Noise gate

Pre distortion equalisation

Pre EQ

Multiband, distortion, and volume effects

Guitar Synthesizer
Multiband Distortion
Multiband Echo
Multiband Fuzz
Tremolo
Distortion